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How Far Can Trinitromethyl Substitution Be Pushed on a Single 1,2,3-Triazole Ring?
Journal article   Peer reviewed

How Far Can Trinitromethyl Substitution Be Pushed on a Single 1,2,3-Triazole Ring?

Jatinder Singh, Haixiang Gao, Richard J Staples, Jessica E Burch and Jean'ne M Shreeve
Organic letters, Vol.28(1), pp.299-303
12/21/2025
PMID: 41422540

Abstract

Sequential nitration on a 1,2,3-triazole framework was explored to probe access to a maximally nitrated (nine-nitro) triazole species, although the fully nitrated product could not be isolated. Instead, a heptanitro product formed through a transformation. These results highlight steric and electronic limitations that restrict extreme nitration and clarify how such factors influence stability and synthetic feasibility, offering guidance for future ultranitrated heterocycle design.
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doi.org/10.1021/acs.orglett.5c04680View

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