Abstract
Computer-aided Diagnosis (CADx) based on explainable artificial intelligence (XAI) can gain the trust of radiologists and effectively improve diagnosis accuracy and consultation efficiency. This paper proposes BI-RADS-Net-V2, a novel machine learning approach for fully automatic breast cancer diagnosis in ultrasound images. The BI-RADS-Net-V2 can accurately distinguish malignant tumors from benign ones and provides both semantic and quantitative explanations. The explanations are provided in terms of clinically proven morphological features used by clinicians for diagnosis and reporting mass findings, i.e., Breast Imaging Reporting and Data System (BI-RADS). The experiments on 1,192 Breast Ultrasound (BUS) images indicate that the proposed method improves the diagnosis accuracy by taking full advantage of the medical knowledge in BI-RADS while providing both semantic and quantitative explanations for the decision.